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相关概念视频

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Inflammation01:38

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Introduction to the Integumentary System01:25

Introduction to the Integumentary System

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The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
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相关实验视频

Updated: Jul 10, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
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Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

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皮肤和炎症 - - 衰老

Rashi Agrawal1, Anne Hu1, Wendy B Bollag1,2,3

  • 1Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA 30912, USA.

Biology
|November 24, 2023
PubMed
概括
此摘要是机器生成的。

老化皮肤经历的变化会损害其屏障功能,可能导致全身炎症. 了解这些与年龄相关的皮肤变化是开发治疗老化皮肤和其他组织的关键.

关键词:
老化的老化 衰老的老化亚托邦性皮肤炎的发生.皮肤上皮层屏障的障碍皮肤表皮的表皮.这是一种炎症炎症炎症炎症.角质细胞 (keratinocytes) 是一种细胞.牛皮是一种牛皮.皮肤 皮肤 皮肤射剂是指使用射剂.

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科学领域:

  • 皮肤病学 皮肤病学
  • 老年学是一门学科.
  • 免疫学 免疫学 免疫学

背景情况:

  • 皮肤的独特位置需要重要的保护和代谢功能.
  • 老龄化导致皮肤结构和功能发生显著变化.
  • 随着年龄的增长,皮肤屏障功能受损与炎症有关.

研究的目的:

  • 探索与年龄相关的皮肤变化在炎症中的作用.
  • 调查来自皮肤的"炎症衰老"概念.
  • 突出针对皮肤的治疗方法的潜力.

主要方法:

  • 审查关于皮肤衰老和炎症的现有文献.
  • 对皮肤对全身炎症调解者的贡献进行分析.
  • 探索将皮肤屏障功能障碍与炎症联系在一起的机制.

主要成果:

  • 老化会损害皮肤屏障的功能,增加对损伤的易感性.
  • 老化中的皮肤炎症可能会导致持续的亚临床系统性炎症.
  • 这种"炎症衰老"过程可能是各种与年龄相关的衰退的基础.

结论:

  • 与年龄相关的皮肤变化,特别是屏障功能障碍,是显著的.
  • 皮肤是"炎症衰老"的潜在主要原因之一.
  • 对皮肤衰老机制的进一步研究可能会产生广泛的治疗效益.