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Updated: Jul 10, 2025

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在受体的内在无序区域内引发的新型共价修饰器诱导的局部形态变化

Michael T Harnish1, Daniel Lopez1, Corbin T Morrison1

  • 1Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.

Biology
|November 24, 2023
PubMed
概括

小分子可以改变转录因子中的内在无序区域 (IDR). 连接体和AR IDR之间的特定相互作用通过改变螺旋倾向来中和液态-液态相分离 (LLPS).

关键词:
受体受体是受体的受体.一种共价药物药物.本质上是无序的蛋白质.分子动力学模拟模拟蛋白质构成的结构.

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