饮食成分对杆细胞的影响:可能用作过敏的营养药?
1Institute of Nutritional Medicine, University of Hohenheim, D-70593 Stuttgart, Germany.
Cells
|November 24, 2023
概括
像维生素D和氨酸这样的食化合物可以通过减少炎症来帮助控制过敏. 研究强调了它们作为营养保健品的潜力,尽管生物可用性仍然存在挑战.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 过敏性疾病影响全球30%的人口.
- 乳腺细胞 (MC) 是过敏反应的核心,释放炎症介质.
- 饮食成分可能调节MC活性,为过敏提供潜在的营养药益处.
研究的目的:
- 审查饮食成分对乳腺细胞的抗炎作用.
- 探索这些影响所涉及的潜在信号通路.
- 评估这些成分在临床前和临床环境中的疗效.
主要方法:
- 实验室和体内研究检查饮食成分对乳腺细胞的影响.
- 分析介导抗炎作用的信号通路.
- 对过敏性鼻炎 (AR) 患者进行随机对照试验 (RCT) 的综述.
主要成果:
- 丁酸盐,酸,kaempferol,Quercetin,luteolin,resveratrol,curcumin和肉提取物在模型中显示出显著的MC介质抑制.
- 维生素D,氨酸,EGCG,白醇,黄素和肉提取物在RCT中改善了AR症状并减少了炎症细胞.
- 这些营养素的生物可用性较差是一个关键的挑战,需要进一步研究.
结论:
- 特定的饮食成分对巨细胞表现出强大的抗炎作用.
- 几种营养保健品已经证明对过敏性鼻炎的临床益处.
- 提高这些有益的饮食化合物的生物可用性对于治疗进步至关重要.
相关概念视频
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
307
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
307
Allergic Reactions
27.5K
Overview
27.5K
Allergic Drug Reactions
849
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
849
Antibody Structure
60.2K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.2K
Cross-reactivity
31.2K
Overview
31.2K
Hypersensitivities
684
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
684


