血清丸激素与大动脉狭窄之间的关联:一项前性队列研究
Jari A Laukkanen1,2,3, Carl J Lavie4, Setor K Kunutsor5
1Institute of Public Health and Clinical Nutrition, University of Eastern Finland, P.O. Box 1627 Kuopio, Finland.
Journal of cardiovascular development and disease
|November 24, 2023
概括
男性血清丸激素水平较高与大动脉狭窄症 (AS) 的风险增加有关. 这一发现表明丸激素和心血管健康之间存在潜在的联系,因此需要进一步调查AS预防策略.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 血清丸激素与动脉样硬化心血管疾病有关.
- 大动脉狭窄 (AS) 与心血管疾病具有共同的风险因素.
- 血清丸激素和AS之间的关联以前没有被研究过.
研究的目的:
- 为了前性地研究血清丸激素水平与AS发展风险之间的关联.
- 为了确定较高的丸激素水平是否与男性AS发病率的增加有关.
主要方法:
- 一项前性队列研究,涉及2577名年龄在42-61岁之间的男性.
- 在基线使用放射性免疫测试测量血清丸激素.
- 使用危险比率 (HRs) 估计AS风险,平均随访时间为27.2年,并对多种心血管风险因素进行调整.
主要成果:
- 在随访期间记录了119例AS病例.
- 随着血清丸激素水平在25-39nmol/L之间,AS风险持续增加.
- 调整后的HR值为1.39 (95% CI,1.10-1.76) 每增加10nmol/L的血清丸激素.
- 通过比较血清丸激素的最高和最低三分之一,对AS的调整后风险估计分别为1.76 (1.11-2.81) 和1.76 (1.10-2.80).
结论:
- 血清丸激素水平升高与中老年和老年芬兰男性AS风险增加有关.
- 这些发现强调了丸激素在AS病变发生过程中的潜在作用.
- 需要进一步的研究来证实这些结果,并探索丸激素在AS预防中的相关性.
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