在罗马尼亚眼科诊所的眼睛表面细菌对各种抗生素剂的敏感性
Aurelian Mihai Ghita1,2,3, Daniela Adriana Iliescu1,3, Ana Cristina Ghita3
1Department of Physiology, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Bld., 050474 Bucharest, Romania.
Diagnostics (Basel, Switzerland)
|November 24, 2023
概括
眼球细菌的抗生素耐药性正在增加,影响眼睛感染治疗. 这项研究评估了白内障手术患者的常见抗生素对格拉姆阳性和格拉姆阴性细菌的治疗,发现了有关耐药性模式的发现.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 传染性疾病 传染性疾病
背景情况:
- 定期细菌评估指导用适当的抗生素治疗眼部感染.
- 广泛使用抗生素导致了耐药的微生物菌株,导致眼部感染.
- 眼睛表面细菌对抗生素的敏感性至关重要,特别是在接受白内障手术的患者中.
研究的目的:
- 评估眼睛表面的格拉姆阳性和格拉姆阴性细菌对接受白内障手术的患者常用的抗生素的易感性.
- 为了识别眼睛细菌中新出现的抗生素耐药性模式.
- 为指导眼科临床实践中的抗生素选择提供最新数据.
主要方法:
- 一项涉及993名接受白内障手术的患者 (44岁至98岁) 的研究.
- 结膜培养在手术前7天收集.
- 测试细菌对各种抗生素类别的敏感性,包括糖,素,碳烯,诺,氨基甘油酸,醇,四环素,利法胺素,宏酸和青素.
主要成果:
- 范科米辛在对抗格拉姆阳性细菌时显示出97.8%的疗效.
- 在阳性细菌和阴性细菌中观察到对素 (一种素) 的高耐药性.
- 梅罗,伊米,净,阿米卡和里芬在克拉姆阳性细菌上显示出>90%的疗效.
- 所有测试的诺基诺,氨基糖化物 (除了托布拉米辛),多克西环素,阿齐思罗米辛,克拉里思罗米辛和氨基醇都对格拉姆阴性细菌具有100%的有效性.
结论:
- 这项研究强调了眼睛表面细菌对常见眼科抗生素的抵抗力日益增加.
- 素耐药性是一个重大问题,特别是考虑到其用于预防白内障手术后的内炎.
- 更新的敏感性数据对于眼科中有效的抗生素治疗至关重要.
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