在IBD中的内镜:何时以及如何?
1Gastroenterology Unit, Mauriziano Hospital, 10128 Torino, Italy.
Diagnostics (Basel, Switzerland)
|November 24, 2023
概括
内镜有助于诊断炎症性肠病 (IBD) 和评估严重程度. 标准化内镜评分对于客观评估和临床试验至关重要,尽管可重现性需要进一步关注.
科学领域:
- 胃肠病学 胃肠病学
- 内镜诊断的诊断方法
- 炎症性肠病 (IBD) 的研究.
背景情况:
- 内镜检查,特别是结肠直肠镜检查,对于诊断炎症性肠病 (IBD) 和允许组织学采样至关重要.
- 准确的内镜病变描述可以带来高达89%的准确性诊断.
- 在克罗恩病和性结肠炎中,内镜评估疾病严重程度与不良结果相关,包括增加对先进疗法和住院住院的需求.
研究的目的:
- 审查和讨论有关内镜在炎症性肠病管理中的作用和应用的现有证据.
- 突出验证的内镜评分系统对客观疾病评估和监管要求的重要性.
- 检查中央视频审查的影响和与临床试验中的主观内镜解释相关的可重现性挑战.
主要方法:
- 现有文献和有关炎症性肠病内镜的证据的审查.
- 对性结肠炎 (梅奥内学子评分,UCEIS) 和克罗恩病 (鲁特盖茨评分,CDEIS,SES-CD) 验证的内评分系统的讨论.
- 分析中央内镜视频审查在临床试验中的作用及其影响.
主要成果:
- 内镜检查结果对IBD的诊断和严重程度的评估有显著的贡献.
- 验证的内镜评分对于客观的疾病活性测量和药物反应评估至关重要,与监管标准保持一致.
- 在试验中,集中式内镜视频审查是标准的,但由于主观的图像解释,得分的可重现性是不完美的.
结论:
- 内镜对于IBD诊断,严重程度评估和监测治疗反应是不可或缺的.
- 经过验证的内镜评分的一致应用对于客观评估和跨研究的可比性至关重要.
- 解决内镜解释中固有的主观性是必要的,以提高临床研究发现的可靠性.
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