在COVID-19住院患者的炎症和静脉血栓塞栓症
Angelos Liontos1, Dimitrios Biros1, Rafail Matzaras1
11st Division of Internal Medicine & Infectious Diseases Unit, University General Hospital of Ioannina, Faculty of Medicine, University of Ioannina, 45500 Ioannina, Greece.
Diagnostics (Basel, Switzerland)
|November 24, 2023
概括
炎症标志物如淋巴细胞减少和高中性粒细胞与淋巴细胞的比率与静脉血栓栓塞 (VTE) 的住院COVID-19患者的更糟糕结果有关. 高肺病负担也预示着更差的预后.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 越来越多地认识到COVID-19中炎症和静脉血栓栓塞 (VTE) 之间的联系.
- 了解炎症在COVID-19 VTE结果中的作用对于患者管理至关重要.
研究的目的:
- 调查VTE诊断的住院成人COVID-19患者的炎症标志物和疾病结果之间的关联.
- 确定特定的炎症指数是否能预测该患者群体的严重程度和死亡率.
主要方法:
- 对532名住院COVID-19患者 (2020年3月-2022年5月) 的回顾性观察研究.
- VTE定义为肺栓塞 (PE) 和/或血管树在芽.
- 肺部疾病负担 (CTBoD) 量化为受影响的肺瘤的%.
- 结果包括死亡,输管和住院时间 (LoS).
主要成果:
- 在11.2%的队列中发现了VTE.
- 淋巴细胞减少和高中性粒细胞/淋巴细胞比率与输管和死亡风险增加有关,分别.
- >50%的CTBoD与更高的输入管和死亡风险有关.
- 三糖-葡萄糖 (TyG) 指数与较差的结果相关.
结论:
- 在COVID-19患者中,炎症指数与VTE显著相关.
- 淋巴细胞减少和中性粒细胞与淋巴细胞的比率升高会对预后产生负面影响.
- 需要进一步的研究来确认这些指数对COVID-19相关的VTE结果的影响.
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