肝细胞癌 (HCC) 免疫疗法的进展
Fuat Bicer1, Catrina Kure2, Anil A Ozluk3
1Division of Hematology Oncology, Department of Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
Current oncology (Toronto, Ont.)
|November 24, 2023
概括
使用免疫检查点抑制剂 (ICI) 的肝细胞癌 (HCC) 治疗显示出有限的反应率. 通过基因组分析了解抵抗机制是优化晚期肝癌免疫治疗的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 先进的HCC需要有效的全身疗法,免疫检查点抑制剂 (ICI) 提供了新的选择.
- 然而,原发性或获得性耐药性在约三分之二的患者中限制了ICI的疗效.
研究的目的:
- 审查基于ICI的治疗方法的临床试验结果,用于高级HCC.
- 在肝脏瘤微环境的背景下探索对ICI耐药性的机制.
- 讨论使用生物标志物和基因组改变优化免疫疗法.
主要方法:
- 对高级HCC中已批准的ICI疗法的关键临床试验数据的审查.
- 关于HCC瘤微环境和免疫逃避的科学文献分析.
- 检查与ICI耐药性相关的瘤生物标志物和基因组改变的研究.
主要成果:
- 基于ICI的疗法已被批准用于晚期HCC,但客观响应率约为33%.
- 肝脏的免疫抑制微环境和特定的瘤突变有助于免疫逃避.
- 基因测序可以识别耐药性机制,并为组合疗法策略提供信息.
结论:
- 对抗性机制的进一步研究对于改善高级HCC结果至关重要.
- 基于瘤基因组学和生物标志物的个性化免疫治疗策略具有前景.
- 优化ICI治疗需要更深入地了解HCC中的瘤免疫相互作用.
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