男性乳腺癌的临床,病理和预后特征:一个多中心研究
Francesca Accomasso1, Silvia Actis1, Carola Minella1
1Gynecology and Obstetrics Unit, Mauriziano Umberto I Hospital, Department of Surgical Sciences, University of Turin, 10128 Turin, Italy.
Current oncology (Toronto, Ont.)
|November 24, 2023
概括
男性乳腺癌 (BC) 的生存率与女性乳腺癌 (FBC) 类似. 然而,由于副作用,男性的辅助内分泌治疗中止率较高,这凸显出需要量身定制的管理策略.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床研究 临床研究
背景情况:
- 男性乳腺癌 (BC) 是罕见的,占男性瘤的不到1%.
- 关于男性BC特征,管理和生存的数据有限,阻碍了具体的治疗指南.
- 了解男性和女性乳腺癌 (FBC) 之间的差异和相似之处对于优化患者护理至关重要.
研究的目的:
- 为了比较男性BC和FBC的临床和解剖病理特征.
- 分析男性和FBC的治疗方法.
- 为了确定男性BC和FBC之间的生存差异.
主要方法:
- 从2006年到2018年的回顾性数据分析.
- 包括49名男性和680名绝经后女性,主要非转移性BC.
- 倾向分数匹配 (PSM) 适用于调整年龄,节点状况,pT和分子亚型.
主要成果:
- 与女性相比,男性BC患者的平均年龄为68.6岁,瘤大小较小.
- 辅助内分泌疗法 (AET) 给73.5%的男性BC患者,与女性 (7.6%) 相比,由于副作用导致的退学率显著更高 (16.3%).
- 在男性BC和FBC之间,即使在PSM后,也没有观察到无疾病生存期 (DFS) 和总生存期 (OS) 的显著差异.
结论:
- 男性的BC和FBC表现出类似的预后因素和生存结果.
- 由于副作用,男性中断AET的更高率需要注意.
- 需要进一步研究在男性BC患者中管理AET的副作用.
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