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形基底细胞癌的临床和分子特征:系统性审查

Santina Conte¹, Sarah Ghezelbash^2,3, Bonika Nallanathan^2,3

¹Faculty of Medicine and Health Sciences, McGill University, Montreal, QC H3G 2M1, Canada.

Current oncology (Toronto, Ont.)

|November 24, 2023

概括

形状基底细胞癌 (morBCC) 是一种侵袭性皮肤癌变体. 本综述综合了 morBCC 流行病学,临床表现和分子特征的当前知识,以改善对这种高风险 BCC 亚型的理解和管理.

科学领域:

皮肤病学皮肤病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

基底细胞癌 (BCC) 是最常见的皮肤恶性瘤,在肤浅的人群中具有显著的终身风险.
某些BCC变体,如形态BCC (morBCC),表现出更具侵略性的行为和更差的预后.
morBCC,占BCC病例的5-10%,与延迟诊断,广泛的局部破坏,复发和转移有关.

结论:

morBCC代表了基底细胞癌的临床显著亚型,需要集中注意.
对morBCC分子基础的进一步研究可能会揭示新的治疗点.
这一系统性审查为研究 morBCC. morBCC. 的临床医生和研究人员提供了基础资源.

关键词:

在 BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC BCC 纤维化的基底细胞癌.形态基底细胞癌 (morpheaform) 是一种基底细胞癌.形态性基底细胞癌瘤硬化基底细胞癌 (SCLC) 是一种基本细胞癌.皮肤癌是皮肤癌.

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