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复合材料的进步及其在生物医学应用中的不断扩大的作用

Sivakamavalli Jeyachandran¹, Hethesh Chellapandian¹, Nemat Ali²

¹Lab in Biotechnology & Biosignal Transduction, Department of Orthodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai 600077, India.

Biomimetics (Basel, Switzerland)

|November 24, 2023

概括

一种新的酸盐 (CS) 和配氧化 (Ni-doped ZnO) 纳米复合物的合成和特征. 这种CS/Ni-doped ZnO材料表现出显著的抗菌和抗癌活性,显示出治疗应用的潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

氧化 (ZnO) 是一种多功能半导体,在各种领域都有应用.
酸盐 (CS) 是一种生物相容和生物降解的多糖,具有固有的抗微生物特性.
纳米复合材料通过在纳米尺度上组合不同的材料来提供协同性能.

研究的目的:

为了合成和表征一种新的氧化物 (CS/Ni-doped ZnO) 纳米复合物.
研究合成纳米复合材料的结构,功能,形态和电化学特性.
为了评估CS/Ni-doped ZnO纳米复合材料的抗菌和抗癌潜力.

主要方法:

沉方法,然后在250°C进行化以进行合成.
使用XRD,FTIR,HR-SEM,TEM,BET和UV-对-NIR光谱学的表征.
通过EIS和CV在酸盐缓冲体 (pH6) 中进行电化学分析.

主要成果:

通过各种分析技术证实了CS/Ni-doped ZnO纳米复合物的成功合成.
由于Ni-doping和CS的结合,观察到较小的带间隙和增强的电子孔对生成.
对*P. vulgaris*具有显著的抗菌活性,对MCF-7乳腺癌细胞具有显著的剂量依赖性细胞毒性 (IC50 ≈ 80μg mL-1).

结论:

这种CS/Ni-doped ZnO纳米复合材料具有有前途的抗菌和抗癌特性.
该材料的特性表明其在生物医学应用中的潜在实用性,包括伤口愈合和癌症治疗.
需要进一步的研究来优化纳米复合材料的临床转化.

关键词:

含有尼奥的 ZnO.它具有抗癌活性,具有抗癌活性.乐队间隙乐队间隙乐队间隙生物聚合物生物聚合物这是一个纳米复合材料.

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