生物仿真系统涉及巨细胞及其潜在的向药物输送
Ivan V Savchenko1, Igor D Zlotnikov1, Elena V Kudryashova1
1Faculty of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1/3, 119991 Moscow, Russia.
Biomimetics (Basel, Switzerland)
|November 24, 2023
概括
使用巨细胞的仿生策略为向药物输送提供了新的方法. 这些方法涉及模仿巨细胞或它们的天然配体,以有效治疗感染,炎症疾病和癌症.
科学领域:
- 生物医学工程 生物医学工程
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 有针对性的药物输送旨在模仿生物系统,以定位到特定的细胞或组织.
- 长期以来,基于红细胞的系统一直在使用,但基于巨细胞的策略正在出现.
- 巨细胞,关键的免疫细胞,为治疗开发提供了一个未充分利用的平台.
研究的目的:
- 审查涉及巨细胞的仿生策略,用于先进的治疗方式.
- 探索使用巨细胞作为药物输送的载体和点.
- 讨论这些系统在治疗感染,炎症和癌症方面的潜力.
主要方法:
- 对基于巨细胞的药物输送系统的现有文献的审查.
- 分析了两个主要的仿生策略:巨模仿和连接体模仿.
- 讨论使用巨细胞衍生颗粒或向巨细胞受体的治疗剂的输送.
主要成果:
- 用巨细胞进行药物输送的两种不同的仿生方法被确定.
- 巨细胞模仿包括使用巨细胞或它们的衍生颗粒作为载体.
- 联结体仿真涉及针对特定治疗剂的巨细胞.
结论:
- 涉及巨细胞的仿生策略对向药物输送具有重大前景.
- 这些方法可用于开发针对感染,炎症和各种癌症的新疗法.
- 进一步研究以巨为中心的仿生学可以彻底改变治疗干预措施.
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