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乳头炎和抗菌S100A7表达在乳制品山羊之间的关系

Yutong Yan^1,2, Kunyuan Zhu^1,2, Haokun Liu^1,2

¹Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Xianyang 712100, China.

Veterinary sciences

|November 24, 2023

概括

在患有亚临床乳腺炎的乳母山羊中,S100A7蛋白被上调,这表明它在宿主防御中的作用. 它在乳腺中的表达在乳腺炎中增加,为这种情况提供了新的见解.

科学领域:

兽医免疫学兽医免疫学
分子生物学分子生物学
乳制品科学乳制品科学

背景情况:

S100A7是一种与炎症相关的蛋白质,对宿主防御至关重要.
关于乳腺炎与乳母山羊S100A7表达之间的关系的研究有限.

研究的目的:

为了研究乳母山羊中S100A7的表达,乳母山羊的乳母炎严重程度各不相同.
为了确定S100A7度,体细胞计数 (SCC) 和乳腺炎状态之间的相关性.
探索S100A7在乳腺腺在乳腺炎期间的宿主防御中的作用.

主要方法:

乳山羊 (n=84) 根据临床症状,SCC和细菌学培养分为健康,亚临床乳腺炎和临床乳腺炎组.
测量了牛奶中的S100A7度和SCC.
评估了乳腺组织中的S100A7表达.
用接收器操作特征 (ROC) 曲线分析来评估诊断潜力.

主要成果:

与健康山羊相比,亚临床乳腺炎山羊的S100A7度显著更高 (p=0.0056).
在log10 SCC和S100A7度 (R=0.05249) 之间观察到正相关性.
ROC分析显示了对log10 SCC (亚临床乳腺炎的AUC=0.9222) 和S100A7 (亚临床乳腺炎的AUC=0.7317) 的诊断潜力.
在乳腺炎山羊的乳腺中,S100A7的表达显著增加.

结论:

在患有亚临床乳腺炎的乳母山羊中,S100A7的表达上调.
在乳腺炎期间,S100A7在乳腺的宿主防御机制中发挥作用.
S100A7可以作为乳制品山羊乳腺炎的潜在生物标志物.

关键词:

在 S100A7A7 中使用.乳制品山羊乳制品山羊是什么意思乳腺炎是一种乳腺炎.身体细胞数量体细胞数量

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