在心力衰竭中患有亚临床心房的患病率与保存的喷射分数
Eunice Yang1, Susan R Heckbert2, Jennifer Ding3
1Inova Schar Heart and Vascular Institute, Fairfax, Virginia, USA; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
JACC. Heart failure
|November 24, 2023
概括
亚临床心房动 (AF) 在心力衰竭患者中比在没有心力衰竭的患者中更常见,心力衰竭患者具有保存的喷射分数 (HFpEF). 在HFpEF患者中早期查AF可能会改善结果.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏衰竭研究研究
背景情况:
- 心房动 (AF) 在心力衰竭中普遍存在,患有保留喷射分数 (HFpEF) 患者,与不良临床结果相关.
- 在HFpEF群体中,亚临床AF的发生率以前没有被确立.
- 亚临床AF检测对于管理HFpEF患者和预防并发症至关重要.
研究的目的:
- 在被诊断为HFpEF的患者中调查亚临床AF的患病率.
- 为了比较HFpEF患者中亚临床AF的患病率与没有心力衰竭史的对照组.
主要方法:
- 亚临床AF的查在没有先前AF诊断的HFpEF患者中进行.
- 使用来自多民族动脉样硬化研究 (MESA) 队列的心电图监测数据进行了比较分析.
- 采用多变量逻辑回归模型,以调整人口和临床因素.
主要成果:
- 该研究包括90名HFpEF患者和1230名MESA参与者.
- 在8.9%的HFpEF患者中检测到亚临床AF,而非HFMESA队列中为4.1%.
- 调整后的分析显示,HFpEF患者中亚临床AF的可能性显著更高 (OR:3.01;95% CI:1.13-7.99;P = 0.03).
结论:
- 与没有心力衰竭的人相比,患有HFpEF的患者表现出更高的亚临床AF患病率.
- 在HFpEF患者中,常规查心房失常症,建议立即启动血栓栓塞预防.
- 识别亚临床AF可能有助于精确确定患有临床恶化风险较高的HFpEF患者.
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