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在姿势性心跳动综合征中进行非侵入性迷你神经刺激:一项随机临床试验

Stavros Stavrakis¹, Praloy Chakraborty¹, Kassem Farhat¹

¹University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

JACC. Clinical electrophysiology

|November 24, 2023

概括

通过皮肤进行的迷走神经刺激 (tVNS) 在POTS患者中显著降低了姿势性心动减速. 这种非侵入性神经调节方法还降低了炎症标志物,改善了自主性基调.

科学领域:

神经学神经学
心脏病学心脏病学
免疫学免疫学免疫学

背景情况:

通过皮肤进行的迷走神经刺激 (tVNS) 显示出抗心律失常和抗炎作用.
初步研究表明,tVNS可能有利于姿势性心律障碍综合征 (POTS) 的动物模型.

研究的目的:

为了评估tVNS在治疗POTS的有效性,在2个月的时间内使用模拟控制,双盲,随机临床试验.

主要方法:

参与者每天接受tVNS (20Hz,1mA) 2个月的1小时,在tragus (n=12) 和假耳叶 (n=14) 进行活跃刺激.
评估包括体位性心动减速测量,心率变化,血清细胞因子和抗自律性自身抗体在基线和2个月.

主要成果:

与假心相比,活性tVNS显著降低了心率的姿势增加 (17.6比31.7次/分钟,P=0.01).
活跃组显示抗上腺体自身抗体和炎症性细胞因子 (P<0.05) 的减少,心率可变性得到改善.
报告了高坚持 (83-86%) 和没有设备相关的副作用.

结论:

通过tVNS进行的非侵入性神经调节显示出治疗POTS的前景.
治疗效果与减少自身抗体,减少炎症和增强自主度有关.
需要进一步的研究来探索tVNS在POTS管理中的全部潜力.

关键词:

这是自抗体的自抗体.自主调制的自主调制这是一种炎症炎症炎症炎症.静止性心力衰竭综合征 (postural tachycardia syndrome) 是一种心力衰竭综合征.

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