在接受德克斯梅托米丁用于MRI的儿科患者中发生的低压事件
Stephanie A Cruz1, Anoop Mayampurath2, Susan C Vonderheid3
1Department of Pediatric Sedation, UChicago Medicine Comer Children's Hospital, Chicago, IL.
概括
低血压发生在接受德克斯梅德托米丁用于MRI的儿科患者中的5.7%. 男性性别和更大的血压变化与降低血压风险增加有关.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 医疗成像安全 医疗成像安全
- 药物监督 药物监督 药物监督
背景情况:
- 德克斯梅德托米丁是一种用于儿科MRI的常见镇静剂.
- 低血压是已知的德克斯梅德托米丁的副作用之一.
- 较新的指导方针建议在儿科手术镇静中对不良事件有两方面的定义.
研究的目的:
- 为了确定患有低血压的儿科患者接受镇静式MRI的发病率.
- 为了确定与低血压相关的人口和临床因素.
- 应用低血压的双重定义 (数值值/临床标准加上干预).
主要方法:
- 对儿童门诊患者 (18岁以下) 进行的观察性队列研究,这些患者在MRI中用德克斯梅德托米丁镇静.
- 从医疗记录中提取的数据超过7年的时间.
- 低血压被定义为持续≥10分钟的20%的缩血压降低,加上液体注射.
主要成果:
- 在1590名患者中,有90人 (5.7%) 患有低血压.
- 男人显著更有可能经历低血压.
- 更长的预约,镇静和恢复时间与低血压有关. 增加BP的变化也增加了风险.
结论:
- 低血压的较低发病率可能是由于基于干预的定义,反映了临床上有意义的事件.
- 这是第一个在这个人群中使用这个定义的研究.
- 需要对镇静时间,血压变化,性别和恢复时间等因素进行进一步的研究,以提高患者的安全性和优化吞吐量.
相关概念视频
Parenteral Anesthetics: Overview
131
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
131
Imaging Studies I: CT and MRI
252
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
252
Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K
Skeletal Muscle Relaxants: Adverse Effects
375
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
375
Depolarizing Blockers: Pharmocokinetics
328
Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
328


