在口腔皮细胞癌的术后放射治疗后的临床结果和失败模式
Saori Tatsuno1, Hiroshi Doi2, Masahiro Inada1
1Department of Radiation Oncology, Kindai University Faculty of Medicine, 377-2, Osaka, Ohno-higashi, Osaka-Sayama, Japan.
概括
手术后放射治疗 (PORT) 对口腔状细胞癌 (OSCC) 有效,包括复发病例. 对主要部位的更高剂量 (>56 Gy) 可能会改善OSCC患者在PORT的结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 头部和部癌症研究研究
背景情况:
- 口腔状细胞癌 (OSCC) 是一个严重的健康问题.
- 手术后放射治疗 (PORT) 是OSCC的关键治疗方式.
- 了解复发模式和优化PORT对于改善患者治疗结果至关重要.
研究的目的:
- 评估用PORT治疗的OSCC患者的复发模式.
- 在OSCC中确定PORT的最佳辐射剂量和目标体积.
- 为了比较PORT在最初诊断的和复发的OSCC中的疗效.
主要方法:
- 对111名接受PORT.治疗的OSCC患者进行了回顾性审查.
- 分析患者人口统计,治疗细节 (剂量,分量) 和随访数据.
- 评估整体存活率,无进展存活率,局部控制和局部区域控制.
主要成果:
- 在初始和复发的OSCC中,PORT证明了有效性.
- 在较低剂量 (≤56 Gy) 到主要部位和较差的无进展生存率和局部控制之间发现了显著的关联.
- 区域节点复发发生在20%的患者中,观察到场内和场外的失败.
结论:
- 波特是OSCC的有效治疗方法,包括初始诊断和术后复发.
- 在接受PORT的OSCC患者中,对主要瘤床的辐射剂量超过56 Gy可能是必要的,以实现最佳的局部控制.
- 对OSCC中PORT的最佳剂量和体积处方进行进一步的研究是有必要的.
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