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Updated: Jul 10, 2025

Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Recapitulation of an Ion Channel IV Curve Using Frequency Components

Published on: February 8, 2011

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由于模型不一致而导致的预测不确定性的实证量化,通过对一组实验设计进行训练:对离子通道动力学的应用

Joseph G Shuttleworth1, Chon Lok Lei2,3, Dominic G Whittaker1,4

  • 1Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Bulletin of mathematical biology
|November 24, 2023
PubMed
概括

数学模型需要准确的不确定性量化,用于生物预测. 本研究建议使用来自不同实验协议的参数集组合来估计因模型差异而产生的不确定性,从而改善模型选择.

关键词:
不一致的差异性 不一致的差异实验设计 实验设计离子通道 离子通道数学模型是一个数学模型.错误的规范是错误的规范.不确定性量化不确定性的量化.

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Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
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