重新审视功能性失联:对精神分裂症中的三种模型框架的审查
Amritha Harikumar1, Kseniya P Solovyeva1, Maria Misiura1
1The Georgia State University/Georgia Institute of Technology/Emory University Center for Translational Research in Neuroimaging and Data Science (TReNDS Center), 55 Park Pl NE, Atlanta, GA, 30303, USA.
Current neurology and neuroscience reports
|November 24, 2023
概括
精神分裂症研究表明,大脑网络的不连接,特别是大脑 - 脑皮层 - 大脑皮层 (CTCC) 和三重网络,与特定症状如运动缺陷和执行功能障碍相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 精神分裂症涉及复杂的功能性失联.
- 行为和神经成像数据为这些变化提供了洞察力.
- 最近的研究集中在特定的大脑网络和病因模型上.
研究的目的:
- 审查最近的精神分裂症连接文献.
- 检查与大脑 - thalamo - 皮层 (CTCC) 和三重网络集相关的发现.
- 将连接性发现与精神分裂症病因的假设模型联系起来.
主要方法:
- 审查2017年至2023年期间发表的休息状态fMRI研究.
- 分析CTCC和三重网络集中的连接发现.
- 结合发现与神经发育,脆弱性压力和神经递质假设.
主要成果:
- 由神经递质和神经发育模型解释的CTCC-皮质下功能障碍,与症状严重程度和运动症状有关.
- 三重网络失联与执行职能缺陷有关.
- 突出网络 (SN) - 默认模式网络失联与思维障碍和注意力缺陷相关.
结论:
- 特定的大脑网络功能障碍与精神分裂症的独特行为症状有关.
- 神经递质和神经发育模型为了解CTCC-皮下功能障碍提供了一个框架.
- 这一综述将观察到的症状与潜在的神经机制联系起来.
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