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头部运动功能障碍与2型糖尿病患者左心室静脉功能受损有关:一项横截面研究
1Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital, Sun Yat-Sen University, No. 600, Tianhe Road, Guangzhou, 510630, China.
在2型糖尿病 (T2DM) 中,运动功能的恶化与左心室 (LV) 扩张功能受损有关. 皮肤电化学导电性 (ESC) 可以作为一种生物标志物,用于检测T2DM患者的心脏扩张性损伤.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 在2型糖尿病 (T2DM) 患者中,心力衰竭与保留喷射分数 (HFpEF) 的患病率正在上升.
- 糖尿病神经病变,特别是小纤维神经病变,与HFpEF的发展有关.
- 在T2DM中,运动功能 (小纤维神经病变的指标) 和左心室 (LV) 扩张功能障碍之间的联系尚不清楚.
研究的目的:
- 调查T2DM患者中动功能和LV透静功能之间的关联.
- 为了确定 sudomotor 功能是否可以作为一个生物标志物为 LV 扩张性损伤在这个人群中.
主要方法:
- 699名T2DM患者根据使用SUDOSCAN的电化学皮肤导电性 (ESC) 被分为三个组:没有,中度和严重的功能障碍.
- 通过多普勒回声心脏成像来评估LV静脉扩张功能.
- 用皮尔森的相关性,逻辑回归和ROC曲线分析来评估这些关系.
主要成果:
- 与没有功能障碍的患者相比,中度和严重的气运动功能障碍患者表现出较差的LV扩张功能指标 (较高的A,E/e';较低的e').
- ESC与心声学参数有显著的相关性,ESC降低与扩张功能受损相关.
- ESC独立预测了 LV 扩张功能受损,ROC 分析表明其作为生物标志物的实用性.
结论:
- 运动功能的恶化与T2DM中下降的LV扩张功能相关.
- 皮肤电化学导电性 (ESC) 显示出其作为一种有价值的生物标志物,可用于识别2型糖尿病患者的LV透静性损伤.
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