在神经性厌食症中PCSK9和勒的血水平
Federico Bigazzi1, Carlotta Francesca De Pasquale2, Sandra Maestro2
1U.O. Lipoapheresis and Center for Inherited Dyslipidemias, Fondazione Toscana Gabriele Monasterio, Pisa, Italy.
概括
患有神经性厌食症 (AN) 的青少年女性表现出更高的proprotein转化酶亚素/kexin类型9 (PCSK9) 和较低的瘦素水平. 这表明AN中的脂质代谢发生变化,影响心血管风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 心血管疾病风险因素 心血管疾病风险因素
背景情况:
- 蛋白转化酶亚提利辛/凯辛9型 (PCSK9) 调节低密度脂蛋白胆固醇 (LDL-C).
- 莱普在心血管风险和PCSK9通路的潜在调节中的作用需要研究.
- 营养状况可能会影响PCSK9和瘦素水平,特别是在饮食障碍中.
研究的目的:
- 评估厌食症神经性 (AN) 的青少年女性的脂蛋白概况,PCSK9和瘦素水平.
- 了解AN中与心血管风险相关的代谢变化.
- 探索AN,PCSK9和瘦素之间的关系.
主要方法:
- 病例控制观察性研究.
- 包括20名患有AN的青少年女性和20名年龄和性别匹配的对照.
- 测量脂蛋白概况,PCSK9和瘦素水平.
主要成果:
- 与对照组相比,患有AN的患者的BMI,总胆固醇和LDL-C都较低.
- 脂蛋白水平对于AN受试者而言保持在正常范围内.
- 在AN受试者中观察到显著更高的PCSK9水平 (+24%) 和较低的瘦素水平 (-43%).
结论:
- 在AN受试者中增加PCSK9和降低勒丁水平需要进一步调查.
- 肝脏和脂肪组织在AN中PCSK9/LDL代谢中的作用需要阐明.
- 研究结果表明,这对患有AN的青少年心血管风险管理有潜在的影响.
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