基于β-环氧德克斯的皮克林乳液以输送α-托科菲醇:抗氧化稳定性和生物可访问性
Caiyun Cheng1, Chao Yuan1, Bo Cui1
1State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China; School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Food chemistry
|November 24, 2023
概括
与单独的β-cyclopodextrin相比,丁甲/β-cyclopodextrin皮克林乳液提供了较强的抗氧化稳定性和更好的消化释放. 这种配方显示出改善营养供应和生物可用性的潜力.
科学领域:
- 食品科学与技术 食品科学与技术
- 合体和表面化学
- 材料科学 材料科学 材料科学
背景情况:
- 皮克林乳液稳定于β-cyclodextrin (β-CD),容易发生氧化降解.
- 丁甲 (CIN) 可能会增强β-CD皮克林乳液的稳定性和功能.
研究的目的:
- 在氧化和消化条件下制备和研究肉甲/β-环德 (CIN/β-CD) 皮克林乳液的稳定性.
- 为了比较CIN/β-CD皮克林乳液与β-CD皮克林乳液的性能.
主要方法:
- 准备β-CD和CIN/β-CD皮克林乳液.
- 氧化稳定性的评估使用麦隆迪阿尔海德 (MDA) 值.
- 研究体外消化行为,包括自由脂肪酸 (FFA) 的释放.
- 对α-托科菲罗尔输送的药理动力学分析.
主要成果:
- CIN/β-CD复合材料在油水界面表现出优异的分散,形成了一个更稳定的界面层.
- 与β-CD皮克林乳液相比,CIN/β-CD皮克林乳液对氧化敏感性明显较低 (MDA值较低).
- 消化实验显示,在小肠中释放内部油相,FFA释放率为44.32±1.08%.
- 药理动力学研究表明,在服用CIN/β-CD皮克林乳液5小时后,α-托科菲罗尔的峰值度 (Cmax) 为64.32±6.45mg/L (Tmax).
结论:
- 将肉甲纳入β-环氧德林皮克林乳液中显著提高了界面稳定性和氧化抵抗力.
- CIN/β-CD皮克林乳液促进了小肠中封装的油相成分的受控释放.
- 开发的CIN/β-CD皮克林乳液显示出有望提高像α-托哥菲醇这样的脂性化合物的生物可用性.
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