在第一期精神病中,语义语言流性缺陷的功能和结构连接相关性
Alfredo L Sklar1, Fang-Cheng Yeh2, Mark Curtis1
1University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA.
第一次情节精神病患者由于大脑连接的改变而表现出语义语言流性 (SVF) 的受损. 它们的功能和结构连接缺乏典型的左向不对称性,右半球过度连接与更差的性能有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 语义语言流 (SVF) 障碍是精神病障碍中的早期和衰弱症状.
- 这些缺陷与前脑,顶脑和脑区域的干扰有关.
- 有效的SVF依赖于功能集成的前-角-平行网内的远程通信.
研究的目的:
- 调查第一发精神病 (FESz) 中SVF缺陷背后的功能性和结构性大脑连接的破坏.
- 为了比较FESz和健康对照 (HC) 之间的连接模式.
主要方法:
- 33个FESz和34个HC完成了用于SVF评估的动物命名任务.
- 在一个秘密的SVF任务中,磁脑镜 (MEG) 测量了功能连接 (相锁定值,PLV).
- 扩散成像测量了弧形带的分数异构性 (FA),这是一个关键的白质道.
主要成果:
- 与HC相比,FESz的SVF得分明显较低.
- 虽然整体PLV和FA没有差异,但FESz缺乏在HC中观察到的左侧化不对称性.
- 在FESz中,右半球增加的PLV与较差的SVF和更长时间的未经治疗的精神病 (DUP) 相相关.
结论:
- FESz在前--平行线网络连接中表现出左向不对称性减少.
- 在FESz中,泰达频段的超连接性可能表明执行功能的混乱和前脑认知控制缺陷.
- 疾病发作时异常的连接模式突出显示了在风险人群中研究半球不对称的发展的必要性.
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