细菌酸盐介导着西利宾的抗动脉样硬化作用
Hao-Ran Shen1, Zhi-Yu Wang1, Zhen Shen1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|November 24, 2023
概括
西利宾 (SIL) 通过促进产生丁酸盐的有益肠道细菌来有效治疗动脉样硬化 (AS). 这提高了营养吸收,减少了炎症,改善了血管健康.
科学领域:
- 心血管科学 心血管科学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 动脉样硬化 (AS) 是一种慢性炎症性疾病,其特点是动脉中积聚斑块.
- 来自乳的化合物西利宾 (SIL) 显示出治疗肝脏和脂质疾病的潜力.
- 在治疗AS的SIL的疗效和机制需要进一步的研究.
研究的目的:
- 为了评估Silybin在高脂肪饮食中的ApoE敲击小鼠对动脉样硬化的治疗效果.
- 阐明Silybin作用的潜在机制,重点关注肠道微生物群和代谢物生产.
主要方法:
- 在使用高脂肪饮食的ApoE淘汰赛小鼠中诱导了动脉样硬化.
- 小鼠被用Silybin (SIL) 治疗.
- 进行了16S rRNA基因测序,抗生素治疗和分子分析,以评估肠道微生物群,酸盐生产,基因表达和AS标志物.
主要成果:
- 西利宾显著减少了大动脉斑块的形成,高脂血症和血管粘附分子.
- 在SIL治疗中,通过调节Butyl-CoA:乙酸CoA转移酶 (BUT) 的作用,增加了肠道丁酸盐的产生.
- 通过MCT1和MCT4运输体,SIL增强了丁酸盐的吸收,改善了肠道完整性,并减少了炎症.
结论:
- 西利宾通过调节肠道细菌来减轻动脉样硬化,以增加丁酸盐的产生和吸收.
- SIL的机制包括提高丁酸盐的生物可用性,恢复肠道屏障功能,抑制炎症.
- 这项研究强调SIL是通过肠道微生物群干预来治疗AS的一种有前途的治疗剂.
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