用两种mRNA疫苗免疫接种后的不同免疫反应
Tetsuo Nakayama1, Reiko Todaka1, Akihito Sawada1
1Laboratory of Viral Infection, Ömura Satoshi Memorial Institute, Tokyo, 108-8641, Japan.
概括
与BNT162b2.2.相比,mRNA-1273疫苗产生了更强的中和抗体 (NAb) 反应和更广泛的针对COVID-19变体的交叉反应. 辅助剂量在两个疫苗组中增强了抗体和细胞因子的产生.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 研究了对BNT162b2和mRNA-1273mRNA疫苗的免疫反应.
- 免疫接种后评估中和抗体 (NAb) 和细胞因子生产.
研究的目的:
- 将BNT162b2和mRNA-1273.3的免疫性进行比较.
- 评估抗体和细胞因子反应随着时间的推移和针对SARS-CoV-2变种.
主要方法:
- 在初级和强剂后,在多个时间点测量NAb标位.
- 测试的细胞因子生产 (Th1,Th2,炎症) 使用全血培养刺激与尖抗原.
主要成果:
- mRNA-1273显示了较高的NAb标位和更广泛的交叉反应性对抗德尔塔和Omicron变异.
- mRNA-1273诱导了更强大的Th1,Th2和炎症性细胞因子反应.
- 增强剂量显著提高了NAb和细胞因子水平;无症状感染也提高了反应.
结论:
- mRNA-1273引发了优越的NAb反应和交叉变异反应.
- 与BNT162b2.2.2相比,mRNA-1273显示了增强的细胞因子诱导.
- 两种疫苗都受益于增强剂量,感染进一步增加了免疫反应.
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