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肠球菌感染性内心炎 - 连续使用zylpenicillin和ceftriaxone的放出后治疗:一个回顾性队列研究

Yael Szterenlicht¹, Yoed Steinmetz², Ziv Dadon²

¹Medicine Department, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

|November 24, 2023

概括

肠球菌感染性内心炎 (EIE) 越来越常见,影响年龄较大,残疾较多的男性. 甲素和 ceftriaxone 的安全性和疗效与EIE 的标准治疗方法相似.

科学领域:

传染性疾病传染性疾病
心脏病学心脏病学
临床微生物学临床微生物学

背景情况:

肠球菌感染性内心炎 (EIE) 是一个重大的临床挑战.
目前的治疗通常涉及诸如青素/皮素与 gentamicin 或皮素与 ceftriaxone 等组合.
长期的门诊治疗需要探索替代治疗方案.

研究的目的:

描述IEE的发病率和患者特征.
评估使用zylpenicillin和ceftriaxone治疗的EIE病例的结果.
为了比较EIE与由其他病原体引起的传染性内心炎 (IE).

主要方法:

回顾性单中心研究 (2016-2021年).
包括所有被诊断患有IE的患者.
将EIE病例与来自其他病原体的IE病例进行比较,并分析EIE门诊治疗策略.

主要成果:

在222个IE病例中,IEE占20%,去年发病率上升到30%.
EIE患者年龄较大,主要是男性,残疾人较多.
用zylpenicillin和 ceftriaxone进行门诊治疗的复发率和死亡率与其他疗法相比相当.

结论:

脑电损伤是IE的新兴主要原因,特别是在老年,更具残疾的男性人口中.
烯和 ceftriaxone 的组合似乎是EIE 治疗的安全有效的替代方案.
需要进行进一步的研究,以巩固zylpenicillin和 ceftriaxone在EIE管理中的作用.

关键词:

塞夫特里亚克松是一种肠球菌 (Enterococcus) 是一个细菌.感染性内心炎感染性内心炎青素是一种青素.治疗疗法治疗疗法

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