植物分子从传统到纳米形式:帕金森病的下一代方法
Sweta Priyadarshini Pradhan1, P Tejaswani1, Anindita Behera1
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University, Bhubaneswar, Odisha, India.
Ageing research reviews
|November 24, 2023
概括
通过使用植物分子,天然抗氧化剂,可以改善帕金森病 (PD) 的管理. 纳米技术增强了它们通过血脑屏障的传递,以获得更好的神经保护.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 包括帕金森病 (PD) 在内的神经退行性疾病在全球范围内正在上升.
- 患病的发病包括氧化应激,神经炎症和黑色物质中的α-synuclein聚合.
- 目前PD的治疗策略在预防神经退行和保护尼格罗斯特里亚特通路方面是有限的.
研究的目的:
- 审查植物分子在帕金森病中的治疗潜力.
- 探索纳米技术战略,以提高植物分子向大脑的输送.
- 为了应对溶解度低,血脑屏障 (BBB) 透性差,植物分子生物可用性有限的挑战.
主要方法:
- 对植物分子,帕金森病和纳米技术研究的文献综述.
- 对PD的机制和植物分子的抗氧化特性研究的分析.
- 检查各种纳米配送系统,旨在改善跨BBB的药物运输.
主要成果:
- 植物分子表现出显著的抗氧化和抗炎性质,有利于PD.
- 纳米技术为克服植物分子的药物动力学限制提供了有前途的解决方案.
- 工程纳米颗粒可以提高PD模型中植物分子的脑向和治疗效果.
结论:
- 植物分子代表了帕金森病的可行的治疗途径.
- 纳米技术对于优化植物分子在神经退行性疾病中的临床应用至关重要.
- 对纳米植物药物的进一步研究可能会导致PD和其他神经疾病的新疗法.
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