在巴西南部患有急性淋巴细胞白血病的儿科患者中爆发了抗万科米辛的Enterococcus faecium ST1133疫情
Thaís Muniz Vasconcelos1, Dany Mesa1, Luiza Souza Rodrigues2
1Faculdades Pequeno Príncipe (FPP), Curitiba, Paraná, Brazil; Instituto de Pesquisa Pelé Pequeno Príncipe (IPPPP), Curitiba, Paraná, Brazil.
Journal of global antimicrobial resistance
|November 24, 2023
概括
在患有白血病的儿童中调查了抗万科素的Enterococcus faecium (VREfm) 疫情. 全基因组测序确定了ST117血统,突出了对抗微生物药物管理的需要,以控制易受伤害的患者中VREfm的传播.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 抗万科素的Enterococcus faecium (VREfm) 构成重大威胁,特别是在免疫功能低下的人群中.
- 患有血液性恶性瘤的儿科患者面临VREfm殖民和感染的高风险.
研究的目的:
- 在小王子医院的儿科患者中调查VREfm的爆发.
- 描述涉及的VREfm菌株的遗传构成和抵抗机制.
主要方法:
- 全基因组测序 (WGS) 用于分析VREfm分离物.
- 用于物种识别的矩阵辅助激光吸附离子化飞行时间质谱法 (MALDI-TOF MS).
- 进行了抗微生物敏感性测试 (MIC) 和in silico多部位序列类型化 (MLST).
主要成果:
- 来自两名患有急性淋巴细胞白血病的儿科患者的五个VREfm分离物被确定.
- 所有分离物体都表现出高水平的万科米辛耐药性 (MIC ≥256 mg/L).
- 在WGS中发现了等离子体,插入序列,菌体和多重耐药性 (vanA, ermB, aac(6 olyl) -aph(2 olyl),dfrG) 和毒性基因 (acm, efaAfm) 的存在.
- 所有分离物属于ST117血统 (ST1133通过新型MLST),这是一个已知的流行病菌株.
结论:
- ST117 VREfm血统在儿科患者中传播,引发了严重的担忧.
- 有效的管理需要开发新的抗微生物药物和强大的抗微生物药物管理计划.
- 控制VREfm的传播至关重要,特别是在血病患者中.
关键词:
急性淋巴细胞白血病急性淋巴细胞白血病.抗生素 抗生素是一种抗生素.儿科 儿科 儿科ST117 (ST1133) 这是一本小说.抗万科胺素的恩特洛可克菌 (Enterococcus faecium) 是一种耐药的菌株.更多相关视频
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