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Updated: Aug 7, 2026

The Logic, Experimental Steps, and Potential of Heterologous Natural Product Biosynthesis Featuring the Complex Antibiotic Erythromycin A Produced Through E. coli
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在大肠杆菌 (Escherichia coli) 中对泰勒紫的单选择性生物合成

Feifei Li1, Que Chen2, Huaxiang Deng2

  • 1Shenzhen Key Laboratory for the Intelligent Microbial Manufacturing of Medicines, CAS Key Laboratory of Quantitative Engineering Biology, Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China; School of Life Sciences, Inner Mongolia University, Hohhot, 150100, China.

Metabolic engineering
|November 24, 2023
PubMed
概括

这项研究提出了E. coli中Tyrian紫的新型单生物合成方法,克服了高纯度染料生产的选择性问题. 优化的发酵实现了44.5毫克的L-1标位,最小的色副产品.

关键词:
原酶是一种基酶.一个选择性生物合成.暂时控制控制时间.推罗的紫色是推罗的紫色.λpL/pR-cI857热感应系统的热感应方式

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