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豆蛋白分离物-黄素纳米颗粒的pH驱动制剂有效地增强了抗瘤活性

Jie Ren¹, Hanshuo Wu¹, Zhihao Lu¹

¹Beijing Engineering Research Center of Protein & Functional Peptides, China National Research Institute of Food and Fermentation Industries, Beijing 100015, China.

International journal of biological macromolecules

|November 24, 2023

概括

豆蛋白纳米颗粒显著增强了黄素的作用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

黄素是一种疏水化合物,具有有限的生物可用性.
豆蛋白分离物 (PPI) 是一种植物性蛋白质,具有纳米颗粒配方的潜力.
开发有效的疏水药物输送系统对于治疗应用至关重要.

研究的目的:

开发和表征豆蛋白分离-黄素纳米颗粒 (PPICN).
为了研究PPI和黄素之间的相互作用机制.
评估PPICN增强的抗瘤活性.

主要方法:

使用新的pH组合制备PPICN.
结构特征和分子动力学模拟.
在体外评估抗瘤活性和作用机制.

主要成果:

PPICN实现了高封装效率 (95.69%) 和药物负载 (32.73μg/mg).
黄素的溶解度增加了4000倍以上.
PPICN显示增强的抗瘤活性,降低IC50和通过ROS介导途径诱导的亡.

结论:

豆蛋白分离物是一种有效的封装材料,用于水性化合物,如黄素.
PPICN表现出改善的稳定性和增强的治疗潜力.
这些发现支持开发基于PPI的输送系统,以提高药物的疗效.

关键词:

这是一种抗瘤药物.纳米颗粒纳米颗粒豆蛋白分离物豆蛋白分离物

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