低度内毒性病与社区获得性肺炎中的心血管事件有关
Roberto Cangemi1, Roberto Carnevale2, Cristina Nocella3
1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
The Journal of infection
|November 24, 2023
概括
社区获得性肺炎 (CAP) 与内毒性血症有关,增加了心血管事件 (CVE) 的风险. 较高的脂聚糖 (LPS) 水平与CAP患者的短期和长期CVE相关.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 社区获得性肺炎 (CAP) 与低度的内毒性相关.
- CAP,内毒性和心血管事件 (CVE) 之间的关系仍未得到充分研究.
研究的目的:
- 评估住院CAP患者中CVE的发生率.
- 调查血清脂聚糖 (LPS) 和松素水平与心血管疾病风险之间的关联.
主要方法:
- 在住院期间和长达43个月的时间内,对523名成人CAP患者进行了随访.
- 分析了血清中的LPS和zonulin水平. CVE包括心肌梗塞,中风和心血管死亡.
- 使用后勤和考克斯回归分析来确定CVE的独立预测因素.
主要成果:
- 较高的LPS水平与住院和长期随访期间的CVE发病率增加有显著的关联.
- 与年龄相关的LPS水平,hs-CRP和zonulin.
- 在CAP患者中观察到升高的大肠杆菌DNA,与LPS相关.
结论:
- 在CAP中,低度内毒素与短期和长期的CVE风险有关.
- 需要进一步的研究来探索治疗策略,例如不可吸收的抗生素,以降低LPS水平并改善结果.
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