在一项队列研究中,香烟烟雾暴露与苏格兰犬的泌尿膀癌之间的关联
D W Knapp1, D Dhawan2, A Ruple3
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, 625 Harrison St., West Lafayette, IN 47907, USA; Purdue Institute for Cancer Research, Purdue University, 201 S. University St., West Lafayette, IN 47907, USA.
Veterinary journal (London, England : 1997)
|November 24, 2023
概括
接触二手烟草烟雾是苏格兰 terriers 狗尿癌 (UC) 的重要危险因素. 减少环境烟草烟雾暴露可能有助于预防这种致命的膀癌在狗.
科学领域:
- 兽医瘤学 兽医瘤学
- 环境流行病学环境流行病学
- 狗的健康 狗的健康
背景情况:
- 狗尿癌 (UC) 是狗中经常致命的膀癌.
- 苏格兰犬表现出明显更高的UC倾向,促进有针对性的风险因素研究.
- 识别可修改的风险因素对于预防犬类UC至关重要.
研究的目的:
- 在一群苏格兰犬中确定UC的环境和宿主相关风险因素.
- 为了研究卷烟烟雾暴露与该品种UC发展之间的关联.
主要方法:
- 通过膀癌查研究,对120只苏格兰 terriers (≥6岁) 的队列进行了长达3年的UC发展监测.
- 业主问卷收集了有关潜在环境和宿主因素的数据.
- 用液体染色学质谱法测量尿液中丁氨酸水平,以评估烟草烟雾暴露.
主要成果:
- 在120只狗中,有32只被诊断出了经过活检确认的UC.
- 显著的UC风险因素包括家庭吸烟者 (OR,6.34),靠近沼泽/湿地 (OR,21.23) 和之前的膀感染 (OR,3.87).
- 与没有 (15.0%) 相比,具有可量化的尿中丁度的狗具有更高的UC诊断率 (35.3%).
结论:
- 暴露于二手烟草烟雾是苏格兰牧羊犬犬尿癌的主要可改变的风险因素.
- 环境修改,特别是减少烟草烟雾暴露,可能在UC预防中发挥作用.
- 对环境暴露及其与狗膀癌的联系进行进一步的研究是有必要的.
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