长时间的药物诱导测试比单日的药物诱导测试更好吗? 一个系统的审查和元分析
Prapasri Kulalert1, Phichayut Phinyo2, Anca Mirela Chiriac3
1Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand; Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
The journal of allergy and clinical immunology. In practice
|November 24, 2023
概括
对β-乳酸过敏反应 (BL-HSR) 的扩展药物诱导试验 (DPT) 发现了更多病例,但对单日DPT的附加值尚不清楚. 需要进一步的研究来有效地比较这些方法.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床药理学 临床药理学
- 基于证据的医学基于证据的医学.
背景情况:
- 药物诱导测试 (DPT) 确认或删除β-乳酸过敏反应 (BL-HSR) 的标准化持续时间缺乏.
- 本研究涉及扩展DPT协议的诊断实用性.
研究的目的:
- 评估与单日DPT相比,延长日DPT在BL-HSR确认/删除标签方面的额外诊断价值.
- 分析DPT持续时间对在成人和儿童群体中确定BL-HSR的影响.
主要方法:
- 一个系统的审查和对使用延长日DPT进行BL-HSR的研究的元分析.
- 在MEDLINE,EMBASE,Web of Science和CINAHL数据库中搜索到2023年3月.
- 使用风险差异和风险比率,比较确认BL-HSR的比例.
主要成果:
- 包括来自42项研究的10371个DPT;延长DPT从2天到10天不等.
- 总体BL-HSR患病率为6.96%,在第一天为3.31%,在延长日为3.65%.
- 延长DPT显示了较高的风险比率 (1.94) 的积极反应,但一半发生在第3天. 总共发生了23次严重反应,只有2次在延长DPT期间发生.
结论:
- 在延长DPT期间BL-HSR患病率增加可能是由于第一天的反应,质疑其优越性超过单日DPT.
- 调查结果并没有明确支持延长日DPT与单日DPT相比.
- 为了比较DPT方法,需要进一步研究包括洗期.
相关概念视频
Desensitization and Tachyphylaxis
1.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.8K
Agonism and Antagonism: Quantification
380
When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
380
Dose-Response Relationship: Overview
3.2K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.2K
Pharmacovigilance
857
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
857
Drug Discovery: Overview
8.0K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
8.0K
Clinical Trials: Overview
3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K


