一个miR-137相关的生物风险路径用于精神分裂症与人类大脑的情绪处理有关
Giulio Pergola1, Antonio Rampino2, Leonardo Sportelli3
1Group of Psychiatric Neuroscience, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|November 24, 2023
概括
与精神分裂症风险相关的microRNA-137 (miR-137) 标影响大脑的情绪处理. 大脑中miR-137的低表达与精神分裂症有关,并影响治疗反应.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 精神病学是一个精神病学.
背景情况:
- 微RNA-137 (miR-137) 对大脑发育,神经发生和神经元成熟至关重要.
- 全基因组关联研究将miR-137与精神分裂症风险联系起来,但其在大脑功能中的确切作用尚不清楚.
- 以前的研究表明,miR-137目标与精神分裂症的工作记忆和情绪处理有关.
研究的目的:
- 为了研究与精神分裂症相关的miR-137目标基因的功能性大脑相关性.
- 为了区分miR-137目标在工作记忆和情绪处理中的作用.
- 探索miR-137表达,基因联合表达网络和精神分裂症之间的关系.
主要方法:
- RNA测序分析了死后前额叶皮质样本 (N=522) 来识别对miR-137目标和精神分裂症风险基因丰富的联合表达基因组.
- 在体外实验中操纵了神经母细胞瘤细胞中的miR-137表达,以验证基因组关系.
- 来自基因组的多基因分数与健康志愿者的功能磁共振成像 (fMRI) 数据和精神分裂症患者的治疗反应有关.
主要成果:
- 发现,在4652名参与者中,精神分裂症风险基因在一个生物验证的集合中被共同表达,并为miR-137目标进行了丰富.
- 较低的前额前部miR-137表达介导了miR-137标风险基因的表达增加.
- 预测更大的基因组共同表达的等位基因与健康个体在情绪处理期间增加的前额叶激活相关,并预测精神分裂症患者的治疗反应较差.
结论:
- 这项研究表明,与精神分裂症相关的miR-137向基因表达功能性地涉及情绪处理的神经基质.
- 研究结果强调了miR-137在调节与情绪处理相关的大脑活动中的作用,以及它对精神分裂症病理生理学和治疗的影响.
关键词:
背侧前额皮层的前额皮层.处理情绪的过程.基因共同表达网络是基因的共同表达网络.在RNA测序过程中,RNA测序精神分裂症是一种精神分裂症.微型RNA 137 137 微型RNA 137 微型RNA 137 微型RNA 137 微型RNA 137更多相关视频
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