皮肤水分调节Ficus deltoidea提取物的皮肤水分调节活动
Nor Hazwani Mohd Ariffin1, Rosnani Hasham1, Mohd Amir Asyraf Mohd Hamzah1
1Department of Bioprocess and Polymer Engineering, Faculty of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.
Fitoterapia
|November 24, 2023
概括
优化维特和异素产量的Ficus deltoidea提取物 (EFD) 增强了皮肤屏障功能和水分. 这项研究证实了其通过体外,体内和体内方法改善皮肤健康的潜力.
科学领域:
- 皮肤病学和化品科学
- 自然产品化学 自然产品化学
- 分子生物学分子生物学
背景情况:
- 菲库斯deltoidea具有抗氧化,抗黑色素,和光保护性质,归因于生物标志物维捷辛和异维捷辛.
- 这些特性表明皮肤屏障功能和水分的潜在好处.
研究的目的:
- 优化Ficus deltoidea叶子 (EFD) 的甲醇提取,以最大限度地提高维捷辛和异维捷辛的产量.
- 评估EFD对皮肤屏障功能和水分的疗效,使用体外,体内和体内的方法.
主要方法:
- 盒子-Behnken设计,以优化甲醇度,超声波时间和溶剂-样本比率.
- 定量实时PCR用于评估角质细胞分化标记基因 (转氨酶-1,卡斯帕酶-14,胺合成酶-3,卷膜素,费拉格林).
- 在人体体内对人体的疗效研究和在体内分子对接分析.
主要成果:
- 在特定条件下 (77.66%甲醇,20.03分钟超声波,19.88毫升/克比率) 最佳提取得到32.29毫克/g的维特辛和35.87毫克/g的异维特辛.
- 在体外,EFD显著提高了皮肤屏障标记基因 (0.7-9.2折) 的mRNA水平.
- 局部EFD配方在体内增加了43.74% (7日) 和47.23% (14日) 的皮肤水分.
结论:
- 优化的甲醇提取有效地从Ficus deltoidea叶片中产生关键生物标志物.
- EFD在增强皮肤屏障功能和水合方面显示出显著的潜力,并得到了分子和临床证据的支持.
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