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用放射治疗治疗的有限阶段扩散大B细胞淋巴瘤的生存结果

Daniel A Ermann¹, Victoria A Vardell², Harsh Shah³

¹Department of Hematology/Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.

Clinical lymphoma, myeloma & leukemia

|November 24, 2023

概括

放射治疗 (RT) 改善了有限阶段 (LS) 扩散性大b细胞淋巴瘤 (DLBCL) 患者的整体存活率 (OS),当添加到化疗时. 皮肤,头部和部和丸等特定的外节部位显示,RT对OS有显著的好处.

科学领域:

血液学血液学血液学
在瘤学瘤学.
辐射瘤学辐射瘤学

背景情况:

有限阶段 (LS) 扩散性大b细胞淋巴瘤 (DLBCL) 患者具有良好的风险,在不进行放射治疗 (RT) 的情况下具有良好的结果.
对其他LS-DLBCL患者进行RT的益处尚不清楚,特别是关于原发性瘤部位.
这项研究调查了RT对总生存 (OS) 的影响,在基于主要地点的真实世界LS-DLBCL队列中.

研究的目的:

为了确定是否添加RT化疗改善OS在LS-DLBCL患者.
根据原发性瘤部位确定特定的患者亚组,这些亚组受益于RT.
分析RT在LS-DLBCL治疗中的实际有效性.

主要方法:

在2004-2015年间诊断的39,745名LS-DLBCL患者的回顾性分析.
数据来源于国家癌症数据库.
仅用化疗治疗的患者与化疗加RT治疗的患者的结局的比较.

主要成果:

在所有LS-DLBCL患者中,RT补充显著改善了5年后的生存状况 (85%对80%,P<.001).
在节点和节外LS-DLBCL中观察到RT的OS益处.
特定的外部位 (皮肤,软组织,头和部,丸,甲状腺) 显示RT改善了OS,而其他部位 (乳房,骨,肺,肠道) 则没有.

结论:

虽然缺乏共识,但RT加上化疗可能有利于特定的LS-DLBCL亚组.
主要瘤部位是确定LS-DLBCL患者的RT益处的关键因素.
这些发现表明在LS-DLBCL治疗中对RT采取更个性化的方法.

关键词:

DLBCL DLBCL 是一个字母.非霍奇金淋巴瘤 (non-hodgkin lymphoma) 是一种非霍奇金淋巴瘤.总体生存率总体生存率

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