系统性免疫炎症/炎症反应指数和高血压之间的关联:对功能性社区的队列研究
Lin-Lin Ma1, Huan-Bo Xiao2, Jie Zhang1
1Department of Epidemiology and Biostatistics, and Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.
系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 预测高血压风险. 这些炎症标志物的较高水平与患高血压的可能性增加有关.
科学领域:
- 心血管健康 心血管健康
- 炎症生物标志物 炎症生物标志物
- 流行病学 流行病学
背景情况:
- 有限的前性数据存在于炎症和高血压之间的联系.
- 炎症越来越被认为是心血管疾病发展的一个因素.
研究的目的:
- 研究系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 和高血压之间的关系.
- 为了确定高血压风险的预测性炎症细胞标志物.
主要方法:
- 在北京 (2015-2021) 的6003名没有高血压的个体进行前性队列研究.
- 使用限制立方线和后勤回归分析剂量反应关系.
- 对高血压相关性SII和SIRI轨迹组的评估.
主要成果:
- 在6年的随访期间,970名参与者患上高血压.
- SII表明与高血压有显著的非线性剂量反应关系.
- 升高的SII和SIRI与高血压风险增加有关 (SII:RR=1.003;SIRI:RR=1.228).
- 在男性中,SII和SIRI的预测值略高.
结论:
- 无论是SII还是SIRI,都会独立地增加高血压的风险.
- SII和SIRI作为有效的炎症细胞指标,用于预测高血压风险.
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