循环中的利斯塔丁水平升高与死亡和心脏代谢障碍的风险增加有关
Jingxue Pan1, Jan Nilsson2, Gunnar Engström2
1Division of Child Healthcare, Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Clinical Sciences, Lund University, Malmö, Sweden.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|November 24, 2023
概括
高水平的利他丁 (FST) 与较高的死亡率和心力衰竭风险有关,可能是由于糖尿病. FST还可以独立预测中风,冠状动脉事件和慢性病.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 在此之前,高循环的肝类利沙丁 (FST) 与2型糖尿病风险增加有关.
- FST诱导脂肪组织的胰岛素抵抗,这表明在代谢功能障碍中发挥了作用.
研究的目的:
- 调查血FST水平与死亡率之间的关联.
- 探索血FST水平与主要健康结果之间的关系,包括中风,冠状动脉事件,心力衰竭和慢性病.
主要方法:
- 利用基于人口的马尔默饮食癌症心血管队列 (n=4733).
- 将队列数据与国家患者登记册联系起来,以追踪平均22年64年的随访期间的健康结果.
- 采用考克斯回归分析,对多种风险因素进行调整,以评估血FST和结果之间的关联.
主要成果:
- 增加的FST水平与更高的死亡率 (HR 1.05),中风 (HR 1.10),缺血性中风 (HR 1.13),心力衰竭 (HR 1.16) 和慢性病 (HR 1.38) 相关.
- FST与中风,冠状动脉事件和CKD之间的关联即使在没有糖尿病的个体中仍然很重要.
- FST与死亡率或心力衰竭之间的联系部分是由糖尿病介导的.
结论:
- 循环FST的升高是增加死亡率和心力衰竭的危险因素,糖尿病可能起到调解作用.
- 无论糖尿病状况如何,FST独立地与中风,缺血性中风,冠状动脉事件和慢性病有关.
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