更新的心血管健康结构与非酒精性脂肪肝疾病风险之间的关联
Jiaojiao Huang1, Zhuojun Xin1, Qiuyu Cao1
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
根据美国心脏协会的最新指南,高心血管健康 (CVH) 评分与患非酒精性脂肪性肝病 (NAFLD) 的风险降低有关. 这一新得分为NAFLD提供了更好的风险评估.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 美国心脏协会 (AHA) 最近修订了其心血管健康 (CVH) 评估标准.
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 了解NAFLD可修改的风险因素至关重要.
研究的目的:
- 研究更新的AHA CVH评分 (Life's Essential 8) 与NAFLD发病率之间的关联.
- 为了比较新的CVH得分与前一个 (Life's Simple 7) 的预测能力.
主要方法:
- 一项前性研究涉及3266名最初没有NAFLD的成年人,通过超声波进行评估.
- 用修改的生命必需8 (mLE8) 评分来评估心血管健康,包括身体活动,尼古丁暴露,睡眠,BMI,脂质,葡萄糖和血压.
- 参与者根据mLE8分数被分为低,中等和高CVH组,以及根据修改的Life's Simple 7 (mLS7) 根据贫穷,中等和理想的CVH.
主要成果:
- 在长达4.3年的中位数随访期间,诊断出623例新的NAFLD病例.
- 低和中等CVH得分 (mLE8) 的人与高CVH的人相比,患NAFLD的风险明显更高.
- 更新的mLE8 CVH构造表明与NAFLD风险的联系比旧的mLS7构造更为强大.
结论:
- 更高的mLE8心血管健康得分与NAFLD发病率降低的风险有关.
- 修订后的AHA CVH框架 (mLE8) 提供了更有效的CVH状态的分类及其与NAFLD风险的关系.
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