在心力衰竭患者中预防肉症的最佳血清25-基维生素D水平:从剂量-反应关系的洞察力
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Ryohei Nagaoka1, Satoshi Katano2, Toshiyuki Yano3
1Division of Rehabilitation, Sapporo Medical University Hospital, Sapporo, Japan.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|November 24, 2023
概括
维持足够的维生素D水平对于心力衰竭患者来说至关重要,以预防肉类. 最佳血清25-基维生素D (25[OH]D) 度在14.6和31.4 ng/ml之间,以最大限度地降低肉症的风险.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
背景情况:
- 血清中25-氧维生素D (25[OH]D) 含量低与肉类,虚弱和心血管疾病风险有关.
- 高的25[OH]D水平也可能对临床结果产生负面影响.
研究的目的:
- 确定最佳血清25(OH) D度,以最大限度地降低心力衰竭 (HF) 患者的肉症概率.
- 检查血清25 (((OH) D水平与高频率患者的肉症之间的剂量依赖关系.
主要方法:
- 招募了461名高风患者 (平均年龄72岁).
- 使用化学发光免疫试验测量血清25(OH) D.
- 根据2019年亚洲肉病工作组的标准诊断出肉病.
主要成果:
- 49%的HF患者患有肉症.
- 观察到25OH) D水平与肉症风险之间存在U形关系.
- 肉症的风险在<14.6 ng/ml或>31.4 ng/ml的情况下增加,最低风险在20 ng/ml左右.
- <14.6 ng/ml的水平独立地与肉症相关 (aOR:2.16).
结论:
- 在HF患者中,血清25(OH) D和肉症之间存在U形关系.
- 保持血清25 (OH) D在14.6和31.4 ng/ml之间,可能有助于预防高血压炎的肉症.
- 识别和纠正低25OH) D水平 (<14.6 ng/ml) 可以改善高频率患者的肉症风险评估.
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