在以人口为基础的队列中,系统性红斑狼的多发症:中西部狼网络
Gabriel Figueroa-Parra1, Jose A Meade-Aguilar1, Cassondra A Hulshizer2
1Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Rheumatology (Oxford, England)
|November 24, 2023
概括
患有系统性红斑狼 (SLE) 的患者在诊断之前就会经历更高的多病症. 这种发展多种慢性疾病的风险增加在SLE发病后仍然存在,由疾病相关和无关因素驱动.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 慢性疾病管理 慢性疾病管理
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,与显著的发病率有关.
- 多病症,即两种或多种慢性疾病的同时发生,越来越被认为是一个主要的健康挑战.
- 了解SLE多病症的患病率和发病率对于患者护理和资源分配至关重要.
研究的目的:
- 确定SLE患者多病症的流行率和发病率.
- 在SLE患者中调查多病症和SLICC/ACR损伤指数 (SDI) 之间的关联.
- 为了比较SLE患者的多病率与匹配的非SLE比较者.
主要方法:
- 利用SLE患者的流行和发病情况基于人口的队列和匹配的对照.
- 评估了57种慢性疾病,将其分为与SDI相关的或与SDI无关的.
- 定义多病症为存在两个或两个以上的慢性疾病.
- 采用后勤回归来进行流行率比较和Cox模型来研究多发病的发生率和发展.
主要成果:
- 与非SLE比较者相比,患有SLE的患者在流行 (OR 2.98) 和发生 (OR 2.27) 队列中表现出明显更高的多重发病率.
- 在SLE患者的发病后,发展多病症的风险大约是SLE患者的2倍 (HR 2.11).
- 在SLE患者中,与SDI相关的疾病 (HR 2.91) 的多发症发展明显高于与SDI无关的疾病 (HR 1.73).
结论:
- 患有SLE的患者表现出大量的多病症负担,甚至在疾病诊断之前就显而易见.
- 这种多发性疾病风险的增加仍然存在,并在SLE分类后恶化.
- 在SLE的多发性受直接与SLICC/ACR损害指数相关的条件和与之无关的条件的影响.
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