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身体活动和检查点抑制:与毒性和生存率的关联

Rik J Verheijden^1,2, Anna Cabané Ballester¹, Karel C Smit^1,2

¹Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Journal of the National Cancer Institute

|November 24, 2023

概括

在免疫检查点抑制剂 (ICI) 治疗之前,较高的体力活动 (PA) 与较少的严重副作用和可能更长的生存时间有关. 需要进一步的研究来确认增加PA是否有利于接受ICI治疗的患者.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
运动科学运动科学

背景情况:

动物研究表明,身体活动 (PA) 有助于抗瘤免疫力.
关于PA对免疫检查点抑制剂 (ICI) 毒性和有效性的影响,人类数据有限.
这项研究调查了PA与人类ICI相关结果之间的关联.

研究的目的:

评估接受ICI治疗的患者体力活动水平和免疫相关不良事件 (irAEs) 之间的关系.
在接受ICI治疗的患者中,评估身体活动与整体存活率 (OS) 的关联.
为了确定治疗前的PA是否会影响ICI治疗的毒性和疗效.

主要方法:

一项前性研究,包括251名在学术医院接受ICI的患者.
使用SQUASH问卷量化的体力活动,测量总PA和中度至强烈强度PA (MVPA-SL).
后勤和考克斯回归模型用于分析与严重的irAEs和OS的关联,并对混因素进行调整.

主要成果:

较高的总PA水平与严重的irAE发生的几率显著降低相关 (调整后OR:0.34-0.19).
中等和高的PA水平与延长的整体存活率相关 (调整HR:0.58-0.48).
对于MVPA-SL.也观察到类似的积极关联.

结论:

在ICI治疗开始时增加体力活动与严重的IRE风险降低有关.
在接受ICI治疗的患者中,更高的PA水平可能与更好的生存结果有关.
随机对照试验是必要的,以确定因果关系和最佳的PA干预措施.

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