3D生物打印多层脑血管导管,研究与血管几何相关的癌症扩散机制
Wonbin Park1, Jae-Seong Lee2, Ge Gao3
1Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Republic of Korea.
Nature communications
|November 24, 2023
概括
大脑血管的几何形状会影响癌症的传播. 复杂的曲线减缓了瘤细胞,促进了与大脑转移和生长相关的分子变化.
科学领域:
- 生物医学工程 生物医学工程
- 癌症研究 癌症研究
- 神经科学是一个神经科学.
背景情况:
- 大脑血管的复杂几何影响循环瘤细胞的行为.
- 现有的模型无法复制大脑血管微环境来研究大脑转移.
- 了解癌症扩散的物理和分子机制至关重要.
研究的目的:
- 使用3D生物打印创建一个仿生脑血管管道.
- 为了研究血管几何学在大脑转移中的作用.
- 在体外探索癌症扩散的物理和分子机制.
主要方法:
- 使用了浴室内3D三轴生物打印技术.
- 开发了一种特定于大脑的混合生物墨水,配备了一种离子交叉链接的水凝.
- 产生了一个成熟的,三层的脑血管导管,曲率不同.
主要成果:
- 在血管曲率较大的区域,瘤细胞粘附度增加.
- 在低速度和剪切应力下延长瘤细胞居住时间加速了转移性特征.
- 观察到加速的内皮屏障破坏,上皮-介质细胞过渡,炎症和瘤发生.
结论:
- 血管几何学显著影响大脑转移.
- 在曲血管中血流缓慢和剪切应力较低,促进癌细胞扩散和转移性进展.
- 这些发现提供了对大脑转移机制的见解,有助于未来的研究.
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