中部早期青春期与血压轨迹的关联:前性队列研究
Hsien-Yu Fan1,2,3, Wan-Ling Tsai3,4, Kuo-Liong Chien1
1Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Pediatric research
|November 24, 2023
概括
中央早熟青春期 (CPP) 与男孩的缩血压升高和早期高血压有关,特别是在青春期开始后. 这种关联在女孩中没有观察到,突出显示了CPP对血压轨迹的性别特异性影响.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 心血管健康 心血管健康
- 青春期研究 青春期研究
背景情况:
- 血压 (BP) 的性别差异在童年时期出现,但中心早期青春期 (CPP) 的影响尚不清楚.
- 慢性性发育不良症是一种不寻常的早期开始青春期的情况.
研究的目的:
- 调查CPP与早期高血压风险之间的关联.
- 在女孩和男孩中检查与CPP相关的BP轨迹.
主要方法:
- 来自台湾青春期纵向研究的血压数据的纵向分析.
- 包括6至13岁的女孩和10至15岁的男孩,在坦纳阶段2定义青春期的开始.
- 对青春期开始前后血压轨迹的检查,与CPP和高血压风险相关.
主要成果:
- 在男孩中,CPP与早期高血压有显著的关联 (OR,7.45),但在女孩中没有.
- 患有CPP的男孩在青春期开始前 (平均差异6.51) 和青春期开始后 (平均差异8.92) 呈现较高的缩血压,高于正常青春期开始的男孩.
- 患有CPP的男孩血压升高的很大一部分发生在青春期开始后.
结论:
- 中央早期青春期与缩血压升高和早期高血压的风险增加有关,特别是在男孩中.
- 患有CPP的男孩中,大部分血压升高发生在青春期后.
- 准CPP可能会影响成人静脉压,这表明早期干预的潜力.
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