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Updated: Jul 10, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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在三阴性乳腺癌中选择性抑制CDK9

Ebtihal H Mustafa1, Geraldine Laven-Law1, Zoya Kikhtyak1

  • 1Dame Roma Mitchell Cancer Research Laboratories, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Oncogene
|November 24, 2023
PubMed
概括

一种新的选择性循环素依赖性激酶9 (CDK9) 抑制剂CDDD11-8,有效向三阴性乳腺癌 (TNBC) 细胞和瘤. 这种有前途的疗法在TNBC亚型中显示出有效性,在临床前模型中没有观察到毒性.

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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers10:49

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