在胃癌中通过多omics集成,分子对接和机器学习对球菌相关铁灭基因YWHAE的功能进行全面分析
Dingwei Liu1,2,3,4, Jianxiang Peng1,2,3,4, Jun Xie1,2,3,4
1Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Apoptosis : an international journal on programmed cell death
|November 24, 2023
概括
杆菌感染驱动胃癌通过ferroptosis基因YWHAE. 这个基因,这个基因.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 胃癌与杆菌 (H. pylori) 感染有关.
- 在H. pylori相关的胃癌中,分子机制,特别是铁亡,尚不清楚.
研究的目的:
- 研究YWHAE基因在胃癌中的作用.
- 探索YWHAE与H. pylori感染和铁亡的联系.
主要方法:
- 多主题数据分析数据分析.
- 分子对接是分子对接.
- 机器学习 机器学习
- 泛癌分析 泛癌分析
- 一个单细胞分析.
- qRT-PCR和IHC验证的验证方法
主要成果:
- 在H. pylori胃炎和胃癌中,YWHAE被上调.
- YWHAE表达与铁,MAPK,NF-κB和PI3K通路相关.
- YWHAE影响药物敏感性,免疫微环境和瘤突变负担.
- 开发了一个YWHAE相关基因的预后模型.
结论:
- YWHAE是一种关键基因,它将H. pylori感染与胃癌中的铁亡联系起来.
- YWHAE具有作为预后生物标志物和治疗点的潜力.
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