基于污染的强迫症患者的厌恶减少评估条件 (DREC) 和大脑刺激:随机对照试验的协议
Faezeh Raeis Al Mohaddesin1, Ali Moghimi2, Javad Salehi Fadardi3,4
1Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Trials
|November 24, 2023
概括
这项研究测试了评估性调节和大脑刺激是否可以减少强迫症患者的厌恶感. 这些发现可能会提供新的强迫症治疗策略.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 精神病学是一个精神病学.
背景情况:
- 厌恶是基于污染的强迫症 (OCD) 的关键情绪.
- 评估条件化可以改变情绪反应.
- 轨道前皮层 (OFC) 功能障碍与强迫症有关,而OFC的神经调节可能会缓解症状.
研究的目的:
- 调查评估性调节在减少基于污染的强迫症患者的厌恶敏感性的有效性.
- 检查评估性调节和OFC的跨直流刺激 (tDCS) 对厌恶和强迫症症状的联合影响.
- 探索这些干预措施对脑电图 (EEG) 和认知功能的影响.
主要方法:
- 一个单盲,随机对照试验 (RCT) 的2x2因数设计.
- 55名基于污染的强迫症患者被分配到10次真实或虚假的评估调节,并与真实或虚假的阴极tDCS配对到OFC.
- 主要结局包括厌恶强度和临床强迫症症状;次要结局涉及基线,干预后和2个月后期的EEG和认知功能评估.
主要成果:
- 关于厌恶强度和强迫症症状减少的初级结果数据正在等待分析.
- 关于EEG和认知功能变化的二次结果数据正在等待分析.
- 这项试验是第一个在强迫症临床样本中应用评估条件的试验.
结论:
- 这项研究将提供初步证据,证明具有或没有tDCS的评价性调节对强迫症的厌恶减少的有效性.
- 这些发现可能会为强迫症的新型,以情绪为中心的治疗策略提供信息.
- 该研究还将提供关于强迫症治疗反应的神经和认知基础的见解.
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