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开发和评估一种方法来评估乳腺癌风险,使用乳腺扫描密度的纵向历史:一个队列研究
Emma C Atakpa1, Diana S M Buist2,3, Erin J Aiello Bowles2
1Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. e.c.atakpa@qmul.ac.uk.
Breast cancer research : BCR
|November 24, 2023
概括
一种新的纵向乳腺密度测量方法,使用女性的乳房造影史,提供比单次评估更可靠的乳腺癌风险预测. 这种方法提高了接受乳房扫描查的女性的准确性.
科学领域:
- 放射学和成像科学 放射学和成像科学
- 瘤学和癌症研究研究
- 生物统计学和流行病学
背景情况:
- 密集的乳房增加乳腺癌的风险,但当前的测量变化影响准确性.
- 在视觉乳腺密度评估中,读者之间的和读者内部的变化带来了挑战.
- 需要一种可靠的方法来评估乳腺密度随着时间的推移,以改善风险预测.
研究的目的:
- 开发和评估一个纵向乳腺密度测量仪.
- 评估其与侵袭性乳腺癌风险的关联.
- 与标准方法相比,以确定其预测能力.
主要方法:
- 利用了来自132,439名年龄在40-73岁的女性的数据,这些女性接受了多次乳房造影 (1996-2013).
- 使用线性混合模型开发了连续和分类的纵向密度测量.
- 使用危险比率,概率比率统计和一致性指数评估预测能力.
主要成果:
- 纵向密度提供比BI-RADS密度23-35%更大的统计信息.
- 在最密集和最肥胖的纵向类别之间观察到六倍的风险差异 (HR=6.3).
- 在纵向密度 (c-index=0.64) 和 BI-RADS (c-index=0.63) 之间,分辨准确度略高.
结论:
- 使用女性病史的纵向乳腺密度估计比单次测量更可靠.
- 这种方法提高了个体乳腺癌风险估计的准确性.
- 纵向乳房密度具有显著的潜力,可以改善查乳房镜中的风险预测.
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