结肠直肠肝转移:细胞因子可以改变吗?
Costanza Ballarò1, Valeria Quaranta2, Gianluigi Giannelli3
1Laboratory of Molecular Medicine, National Institute of Gastroenterology, IRCCS "S. de Bellis" Research Hospital, Via Turi 27, Castellana Grotte, 70013 Bari, Italy.
Cancers
|November 25, 2023
概括
大肠直肠肝转移 (CRLM) 导致预后不佳. 本综述探讨了瘤微环境中的细胞因子如何调节CRLM,并建议针对细胞因子的组合疗法可以改善结果.
科学领域:
- 在瘤学瘤学.
- 癌症转移研究 癌症转移研究
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 是全球癌症死亡的主要原因.
- 结肠直肠肝转移 (CRLM) 显著恶化了患者的预后,其5年生存率仅为14%.
- 瘤微环境 (TME) 及其细胞通信网络对于推动转移性进展至关重要.
研究的目的:
- 审查细胞因子在CRLM的发展和进展中的多方面的作用.
- 突出TME内的细胞因子网络在调节癌细胞入侵中的重要性.
- 探索针对细胞因子的组合疗法的潜力,以改善CRLM治疗结果.
主要方法:
- 关于研究细胞因子在结肠直肠癌和肝脏转移中的作用的文献综述.
- 对瘤微环境中的细胞通信研究的分析.
- 评估当前的治疗策略和新兴的组合治疗方法.
主要成果:
- 在CRC患者中血清细胞因子水平升高与癌症的发展和进展相关.
- 细胞因子在转移级联的各个阶段都起着关键的调节作用,包括CRLM.
- 在TME内的复杂的细胞因子网络影响癌细胞侵入远处器官.
结论:
- 细胞因子在结直肠肝转移的发病过程中发挥着关键作用.
- 针对特定的细胞因子及其复杂的网络为新的治疗策略提供了一个有希望的途径.
- 组合疗法,将细胞因子向治疗与免疫疗法,化疗或基因疗法相结合,有可能提高CRLM患者的存活率.
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