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缺少ARID1A调节了食道腺癌中的抗瘤免疫反应

Le Zhang1, Yueyuan Zheng1, Wenwen Chien1

  • 1Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Cancers
|November 25, 2023
PubMed
概括

在食道腺癌 (EAC) 中,ARID1A的丧失会增强抗瘤CD8+T细胞的反应. 这种缺陷影响免疫信号和脂肪酸代谢,这表明EAC免疫检查点封锁的新治疗策略.

关键词:
在 ARID1A 里面.CD8+ T 细胞 CD8+ T 细胞国际金融网络的响应IFN的响应消化道腺癌 (adenocarcinoma) 的发生脂质新陈代谢 脂质新陈代谢瘤免疫力 免疫力

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